The 2’,3,4,4’-tetrahydroxy Chalcone criteria for molecular 512-04-9 weight <500Da was modified to <600Da to increase the hit rate, as the big active site of the enzyme require bigger drug molecules to cover it. The set of medicines already in practice manifest severe side effects including nausea, vomiting, diarrhea, headache, insomnia and many other complications. Furthermore the treatment is very expensive, ranging in cost from $177 to more than $400 per month. By taking into account the side effects of chemical drugs, dietary phytochemicals were screened for a purpose to find edible plant sources as an alternate treatment of AD. The top most phytochemical showed 40 more efficient binding with receptor as compared to tacrine, however, none of them were as effective as donepezil. Berberastine, berberine, yohimbine, sanguinarine, elemol and naringenin are the worth mentioning phytochemicals in this context. The concentrations of these phytochemicals in major source plants are given in Table 2. Hydrastis canadensis , containing berberastine and berberine, is a multi-purpose homeopathic remedy. Coptis chinensis is one of the 50 basic herbs used in traditional Chinese medicine and its rhizome is a source of alkaloids like berberine and others. Berberis vulgaris , a shrub that produces edible berries rich in vitamin C, is a good source of berbrine. Ji and Shen reviewed anti-AChE activity of berberine to combat Alzheimer��s disease. They reported the theoretically estimated binding affinities of berberine to the enzyme AChEare very close to the experimental values. Catharanthus lanceus is medicinal plant and contains 6 yohimbine in its leaves. Mroue and coworkers showed anti-AChE activity of ��-yohimbine with IC50 0.431mMin vitro. Sanguinaria canadensis is a historically used medicinal plant by Native Americans. The plant contains sanguinarine and according to Houghton et al. this phytochemical showed in vitro activity of IC50 0.23 ��Magainst bovine erythrocyte AChE. Citrus sinensis contain elemol and naringenin that also showed significant anti-hAChE activity in present study. Heo et al. found out that when naringenin was administered at a concentration of 4
