Product Name: HBXIP Polyclonal Antibody, FITC Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: FITC
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human HBXIP
Clonality: Polyclonal
CAS NO: 117704-25-3
Product: Org 27569
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: HBV X interacting protein; HBX interacting protein; Hepatitis B virus X interacting protein; MGC71071; XIP; HBXIP_HUMAN.
Background: HBXIP (Hepatitis B virus X interacting protein) complexes with the C-terminus of hepatitis B virus X protein (HBx) and down-regulates hepatitis B virus (HBV) replication. When complexed to BIRC5, it interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20338942?dopt=Abstract