Product Name: HES6 Polyclonal Antibody
Applications: WB, IHC-P, IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human HES6
Clonality: Polyclonal
CAS NO: 1219168-18-9
product targets : FGFR inhibitors
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Synonyms: HES-6; bHLHb41; bHLHc23; C-HAIRY1; Transcription cofactor HES-6; Class B basic helix-loop-helix protein 41; Hairy and enhancer of split 6; HES6
Background: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23438475?dopt=Abstract