Product Name :
(S)-Coriolic acid
Description:
(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury.
CAS:
29623-28-7
Molecular Weight:
296.44
Formula:
C18H32O3
Chemical Name:
(9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid
Smiles :
CCCCC[C@H](O)/C=C/C=C\CCCCCCCC(O)=O
InChiKey:
HNICUWMFWZBIFP-IRQZEAMPSA-N
InChi :
InChI=1S/C18H32O3/c1-2-3-11-14-17(19)15-12-9-7-5-4-6-8-10-13-16-18(20)21/h7,9,12,15,17,19H,2-6,8,10-11,13-14,16H2,1H3,(H,20,21)/b9-7-,15-12+/t17-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{Felodipine} MedChemExpress|{Felodipine} Calcium Channel|{Felodipine} Protocol|{Felodipine} References|{Felodipine} manufacturer|{Felodipine} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Fludarabine} web|{Fludarabine} Apoptosis|{Fludarabine} Technical Information|{Fludarabine} Description|{Fludarabine} supplier|{Fludarabine} Epigenetic Reader Domain}
Additional information:
(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury.|Product information|CAS Number: 29623-28-7|Molecular Weight: 296.44|Formula: C18H32O3|Chemical Name: (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid|Smiles: CCCCC[C@H](O)/C=C/C=C\CCCCCCCC(O)=O|InChiKey: HNICUWMFWZBIFP-IRQZEAMPSA-N|InChi: InChI=1S/C18H32O3/c1-2-3-11-14-17(19)15-12-9-7-5-4-6-8-10-13-16-18(20)21/h7,9,12,15,17,19H,2-6,8,10-11,13-14,16H2,1H3,(H,20,21)/b9-7-,15-12+/t17-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.PMID:32672495 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|(S)-Coriolic acid (25μM) causes mitochondrial structural alterations and injury in bronchial epithelium. (S)-Coriolic acid (30 nM; 6 hours; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation.|In Vivo:|(S)-Coriolic acid (0-0.6 mg per mouse; Intranasally once a day for 3 consecutive days) causes severe airway dysfunction, airway neutrophilia, mitochondrial dysfunction and epithelial injury.|Products are for research use only. Not for human use.|
