Rin, the drug of choice in theInt.J.Mol.Sciprevention and remedy of thromboembolic issues, have been related with inefficacy in antithrombin deficient patients with unwanted effects as bleeding and thrombocytopenia.As a result, sulphated types of alginate PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21598360 have already been believed to serve as an option with enhanced activity.Nonetheless, other therapeutic activities attributed to sulphated forms of alginate contains; anticoagulant, antithrombotic, antiatherosclerotic, antiangiogenesis, antimetastatic and antiinflammatory .Xanthan gum produced by Xanthomonas campestris enjoys broad industrial application.Industrial applications are broad and incorporate locations for instance in foods, toiletries, oil recovery, cosmetics and as waterbased paints amongst other.Superior rheological properties shown by xanthan gum let it to become used as rheological handle agent in Talsaclidine Cancer aqueous systems and as stabilizer for emulsions and suspensions .In the agriculture sector, the flow potential in fungicides, herbicides, and insecticides has been enhanced by the addition of xanthan to uniformly suspend strong component in formulations .Pesticide cling and permanence has also been noted to enhance resulting from rheological properties of xanthan.Additionally, ability to disperse and hydrate swiftly at the same time as nonpollution and very good color yield status attributed to xanthan have ensured its use in jet injection printing.Within a bid to go green, formulation of new generations of thermoset coatings has included xanthan gum because it is quite environmentally friendly.Similarly, the petroleum business makes use of xanthan gum in oil drilling, fracturing and pipeline cleaning , and as a result of its exceptional compatibility with salt and resistance to thermal degradation, it is also valuable as an additive in drilling fluids.The functions and properties of some other bacterial exopolysaccharides happen to be summarized (Table).Microbial glycosaminoglycans (GAG) are capsular polysaccharides produced by Escherichia coli K, E.coli K, and Pasteurella multocida.GAGs are structurally linear polysaccharides, composed of repeating disaccharide units derived from amino sugars (glucosamine or galactosamine), hyaluronan, chondroitin and heparan sulphate with uronic acid because the other component with the disaccharide repeat .The biological functions of GAGs consists of molecular camouflage for pathogenic bacteria , nonetheless, these polysaccharides have comparable backbone structure because the industrial heparin and have already been synthesized by Escherichia coli K in the non sulphated forms and within the sulphated types in E.coli K.P.multocida, similarly, produces heparan sulphate with molecular weights amongst and kDa , which is greater than these of E.coli K and E.coli K.GAGs are shed into the atmosphere (fermentation medium) hence; their recovery and modification into biologically active GAGs, like heparin or heparosan sulphate will serve as a vital substitute for animal derived GAGs .Important medicinal products may be obtained from GAG producing bacteria as is definitely the circumstance with Group C Streptococcus (GCS).GCS serves as a vital commercial supply of hyaluronan polysaccharide for surgical, ophthalmic and viscoelastic applications.Int.J.Mol.Sci.Table .Properties and functional attributes of some bacterial exopolysaccharides.Bacteria Exopolysaccharide Dextran Polysaccharide Element Glucose Molecular Weight (Da) Properties Nonionic, superior stability Newtonian, fluid behavior Gelling capacity, film forming High viscosity, Stable more than a wide temperatu.
