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Zhang et al. Parasites Vectors (2015)eight:37 DOI 10.1186/s13071-015-0650-RESEARCHOpen AccessAn association of Aquaporin-4 using the immunoregulation of liver pathology in mice infected with Schistosoma japonicumWeiwei Zhang1, Jifeng Zhu1, Xian Song1, Zhipeng Xu1, Xue Xue2, Xiaojun Chen1, Xiaowei Yang1, Yong Li1, Xiaoxiao Dong1, Sha Zhou1, Wei Li1, Yingying Qian3, Feng Liu1 and Chuan Su1AbstractBackground: Bax Inhibitor site Schistosomiasis is really a chronic parasitic disease that impacts about 200 million people today. In Schistosomiasis japonica and mansoni, parasite eggs have been trapped in host liver and stimulated the CD4+T cell responses to regulate the formation of your granulomas. Subsequently, excessive granulomatous response in some heavily, and/or repeatedly infected folks could lead to chronic liver fibrosis and circulatory impairment. Hence, elucidation from the mechanisms of those responses won’t only present extra information and facts to superior comprehend the mechanisms on the immunoregulation in schistosomiasis, but additionally help to design and style new therapies to handle granuloma-associated immunopathology. The role of aquaporin-4 (AQP4) in water transport has been extensively investigated inside the central nervous technique (CNS). Recently, studies have shown that AQP4 expresses in immune program and lack of AQP4 in mice benefits in substantially much less CD4+CD25+ T regulatory cells (Treg cells) beneath physiological condition, certainly one of the subpopulations of CD4+T cells which restrains immunopathology in hosts with schistoso.
