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EXPERIMENTAL AND THERAPEUTIC MEDICINE 7: 316-322,Effects of atorvastatin loading prior to principal percutaneous coronary intervention on endothelial function and inflammatory components in patients with STsegment elevation myocardial infarctionHUIJUAN YONG1, XIN WANG1, LIN MI1,two, LIJUN GUO1,two, WEI GAO1,2, YONGZHEN ZHANG1,2 and MING CUI1,Department of Cardiology, Peking University Third Hospital, Beijing 100191; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Overall health and Crucial Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, P.R. China Received July 20, 2013; Accepted November 15, 2013 DOI: ten.3892/etm.2013.Abstract. Previous research have demonstrated the helpful effect of statin loading before elective and early percutaneous coronary intervention (PCI), in which the `pleiotropic effects’ of statins might contribute to these clinical rewards.6-Methoxydihydrosanguinarine MedChemExpress The aim of the present study was to examine the possible effects of atorvastatin loading before principal PCI on coronary endothelial function and inflammatory variables in sufferers with acute STsegment elevation myocardial infarction (STEMI).Flavopiridol Autophagy A total of 60 individuals with STEMI have been randomized into 3 groups: Loading dose (80 mg atorvastatin before PCI; n=20), common dose (20 mg atorvastatin prior to PCI; n=20) and handle (without the need of atorvastatin before PCI; n=20). The plasma samples had been collected before, and straight away, 6 and 24 h right after PCI in all the sufferers. The plasma concentrations of endothelial nitric oxide synthase (eNOS), nitric oxide (NO), interleukin6 (IL6), tumor necrosis factor (TNF ) and intercellular adhesion molecule1 (ICAM1) had been examined using ELISA. The plasma eNOS levels promptly and 24 h immediately after PCI had been considerably greater inside the regular dose group compared together with the other groups.PMID:23833812 On the other hand, there had been no substantial variations within the plasma eNOS concentration prior to and 6 h after PCI, or within the plasma NO concentration at any of the timepoints among the 3 groups. The plasma IL6 levels before PCI had been substantially decrease inside the loading dose group compared using the other groups; however, there had been no considerable differences within the plasma concentration of ILfollowing PCI or within the concentrations of TNF and ICAM-1 at any of the timepoints amongst the 3 groups. In conclusion, atorvastatin loading in sufferers with STEMI undergoing main PCI may not have protective effects on endothelia.
