Product Name :
Angoline
Description:
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
CAS:
21080-31-9
Molecular Weight:
379.41
Formula:
C22H21NO5
Chemical Name:
17, 18, 20-trimethoxy-21-methyl-5, 7-dioxa-21-azapentacyclo[11.8.0.0, .0, .0, ]henicosa-1(13), 2, 4(8), 9, 11, 14(19), 15, 17-octaene
Smiles :
CN1C(OC)C2=C(OC)C(=CC=C2C2=CC=C3C=C4OCOC4=CC3=C12)OC
InChiKey:
LVWAKZBZWYHYCJ-UHFFFAOYSA-N
InChi :
InChI=1S/C22H21NO5/c1-23-20-14(6-5-12-9-17-18(10-15(12)20)28-11-27-17)13-7-8-16(24-2)21(25-3)19(13)22(23)26-4/h5-10,22H,11H2,1-4H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.|Product information|CAS Number: 21080-31-9|Molecular Weight: 379.41|Formula: C22H21NO5|Chemical Name: 17, 18, 20-trimethoxy-21-methyl-5, 7-dioxa-21-azapentacyclo[11.8.0.0, .0, .0, ]henicosa-1(13), 2, 4(8), 9, 11, 14(19), 15, 17-octaene|Smiles: CN1C(OC)C2=C(OC)C(=CC=C2C2=CC=C3C=C4OCOC4=CC3=C12)OC|InChiKey: LVWAKZBZWYHYCJ-UHFFFAOYSA-N|InChi: InChI=1S/C22H21NO5/c1-23-20-14(6-5-12-9-17-18(10-15(12)20)28-11-27-17)13-7-8-16(24-2)21(25-3)19(13)22(23)26-4/h5-10,22H,11H2,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{DBCO-Biotin} web|{DBCO-Biotin} PROTAC Linkers|{DBCO-Biotin} TGF-beta/Smad|{DBCO-Biotin} Purity & Documentation|{DBCO-Biotin} Purity|{DBCO-Biotin} custom synthesis} |Shelf Life: ≥360 days if stored properly.{{Tolvaptan} MedChemExpress|{Tolvaptan} Autophagy|{Tolvaptan} Biological Activity|{Tolvaptan} In Vitro|{Tolvaptan} manufacturer|{Tolvaptan} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33232063 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.Products are for research use only. Not for human use.|
