Product Name :
KDEL receptor monoclonal antibody (KR-10)
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The tetrapeptide KDEL, located at the carboxy-terminal sequences of luminal proteins, is a retrieval motif essential for the precise sorting of these proteins along the secretory pathway. KDEL proteins perform essential functions in the endoplasmic reticulum (ER) related to protein folding as well as assembly. The localization of chaperones and other soluble proteins to the ER is achieved by their continuous retrieval from post-ER compartments by the KDEL receptor (Erd2p), which is a membrane protein localized in the Golgi apparatus. Western blot analysis: Lane 1: MW marker, Lane 2: 20µg of HeLa cell lysate (heat shocked), Lane 3: 20µg of 3T3 cell lysate, Lane 4: 20µg of PC-12 cell lysate, Lane 5: 20µg of CHO-K1 cell lysate, Lane 6: 20µg of 3T3 cell lysate (heat shocked), Lane 7: 20µg of PC-12 cell lysate (heat shocked) probed with KDEL Receptor mAb at 1:250. Western blot analysis: Lane 1: MW marker, Lane 2: 20µg of HeLa cell lysate (heat shocked), Lane 3: 20µg of 3T3 cell lysate, Lane 4: 20µg of PC-12 cell lysate, Lane 5: 20µg of CHO-K1 cell lysate, Lane 6: 20µg of 3T3 cell lysate (heat shocked), Lane 7: 20µg of PC-12 cell lysate (heat shocked) probed with KDEL Receptor mAb at 1:250.{{61909-81-7} web|{61909-81-7} Protocol|{61909-81-7} In stock|{61909-81-7} custom synthesis}
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| Alternative Name Lys-Asp-Glu-Leu, Lysine-aspartic acid-glutamate-leucine | Application IHC, WB | Application Notes Detects a band of ~23kDa by Western blot.{{2417371-71-0} web|{2417371-71-0} Purity & Documentation|{2417371-71-0} References|{2417371-71-0} supplier} | Clone KR-10 | Formulation Liquid.PMID:29999795 Mouse ascites fluid containing 0.09% sodium azide. | Host Mouse | Immunogen Synthetic peptide corresponding to a portion of bovine KDEL Receptor. | Isotype IgG1 | Recommendation Dilutions/Conditions Western Blot (1:250, colorimetric)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from mouse ascites. | Species Reactivity Human, Mouse, Rat | Technical Info / Product Notes Recommended by the Human Protein Atlas Organization for IHC (Ensembl No. ENSG00000105438). | UniProt ID P33946 (KDELR1), Q2KJ37 (KDELR2) | Unit of Measure (UM) µl
