Product Name :
CCR4 antagonist 2
Description:
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.
CAS:
2206788-99-8
Molecular Weight:
511.45
Formula:
C26H28Cl2N6O
Chemical Name:
1-[(1R)-1-(2, 4-dichlorophenyl)ethyl]-6-[(4S, 5R)-4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-5-methylcyclohexen-1-yl]pyrazolo[3, 4-b]pyrazine-3-carbonitrile
Smiles :
C[C@@H]1CC(=CC[C@@H]1N1CCC[C@H]1CO)C1=CN=C2C(=N1)N(N=C2C#N)[C@H](C)C1=CC=C(Cl)C=C1Cl
InChiKey:
KQZLRWGGWXJPOS-NLFPWZOASA-N
InChi :
InChI=1S/C26H28Cl2N6O/c1-15-10-17(5-8-24(15)33-9-3-4-19(33)14-35)23-13-30-25-22(12-29)32-34(26(25)31-23)16(2)20-7-6-18(27)11-21(20)28/h5-7,11,13,15-16,19,24,35H,3-4,8-10,14H2,1-2H3/t15-,16-,19+,24+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.|Product information|CAS Number: 2206788-99-8|Molecular Weight: 511.3PO Autophagy 45|Formula: C26H28Cl2N6O|Chemical Name: 1-[(1R)-1-(2, 4-dichlorophenyl)ethyl]-6-[(4S, 5R)-4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-5-methylcyclohexen-1-yl]pyrazolo[3, 4-b]pyrazine-3-carbonitrile|Smiles: C[C@@H]1CC(=CC[C@@H]1N1CCC[C@H]1CO)C1=CN=C2C(=N1)N(N=C2C#N)[C@H](C)C1=CC=C(Cl)C=C1Cl|InChiKey: KQZLRWGGWXJPOS-NLFPWZOASA-N|InChi: InChI=1S/C26H28Cl2N6O/c1-15-10-17(5-8-24(15)33-9-3-4-19(33)14-35)23-13-30-25-22(12-29)32-34(26(25)31-23)16(2)20-7-6-18(27)11-21(20)28/h5-7,11,13,15-16,19,24,35H,3-4,8-10,14H2,1-2H3/t15-,16-,19+,24+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Lenalidomide web |Shelf Life: ≥12 months if stored properly.PMID:32757813 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
