Product Name: GPR58 Polyclonal Antibody
Applications: WB, IHC-P, IF(IHC-P)
Reactivity: Human
Conjugation: Unconjugated
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human GPR58
Clonality: Polyclonal
CAS NO: 874101-00-5
Product: C75 (trans)
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Synonyms: G protein coupled receptor 58; phBL5; GPCR 58; GPR 58; TAAR2; Trace amine associated receptor 2.
Background: Trace amines are endogenous molecules structurally related to classical biogenic amines that are linked to psychiatric conditions. A family of G-protein coupled receptors referred to as trace-amine-associated receptors (TAAR) are activated by trace amines and are present in very low levels in mammalian tissue. TAAR’s contain several structural features that are similar to the rhodopsin beta-adrenergic receptor superfamily, including the positions of the seven transmembrane regions that provide common ligand-binding pockets as well as the short N- and C-terminal domains. TAAR proteins are potential targets for drugs of abuse, such as amphetamine and MDMA, as well as neuropsychiatric disorders including schizophrenia, depression, and attention deficit disorder. TAAR-1 is a 340 amino acid protein that increases intracellular cAMP accumulation in response to beta-phenylethylamine and tyramine. TAAR-1 is associated with the detection of social cues, illustrating its significance as a therapeutic target.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18509551?dopt=Abstract
