Product Name: GPSM1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: ALEXA FLUOR® 555
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human GPSM1
Clonality: Polyclonal
CAS NO: 64887-14-5
Product: TAS-103 (dihydrochloride)
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: Activator of G-protein signaling 3;AGS3;AGS3 homolog;C10a;G protein signaling modulator 1 AGS3 like, C. elegans;G-protein-signaling modulator 1;GPSM1;GPSM1_HUMAN.
Background: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/17601991?dopt=Abstract
