Product Name: GRC5/PHF2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: ALEXA FLUOR® 350
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human GRC5/PHF2
Clonality: Polyclonal
CAS NO: 107753-78-6
Product: BIBF 1202
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: CENP-35; GRC5; JHDM1E; Jumonji C domain containing histone demethylase 1E; jumonji containing protein; Lysine-specic demethylase PHF2; PHD finger protein 2; Phf2; PHF2_HUMAN.
Background: PHF2 is a 1,101 amino acid protein belonging to the PHD finger protein family. Members of the PHD finger protein family function as transcriptional regulators that affect gene expression by modulating chromatin structure. Expressed in a wide variety of tissues, PHF2 localizes to the nucleus and contains one PHD-type zinc finger and one JMJC domain, suggesting a possible role for PHF2 in transcription regulation and chromatin remodeling. The gene encoding PHF2 lies in the candidate region for hereditary sensory neuropathy type I (HSN1), a disorder characterized by sensory dysfunction. PHF2 exhists as two isoforms produced by alternative splicing, designated isoform 1 and 2 respectively.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24303049?dopt=Abstract
