Product Name: HCV-NS4a Polyclonal Antibody, HRP Conjugated
Applications: IHC-P
Reactivity: Virus
Conjugation: HRP
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from HCV-NS4a
Clonality: Polyclonal
CAS NO: 186497-07-4
Product: Daminozide
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
Synonyms: HCV-NS4a; Non-structural protein 4A; NS4A;POLG_HCVBK.
Background: Hepatitis C virus (HCV) is an enveloped, positive-strand RNA virus classified within the genus Hepacivirus in the family Flaviviridae. The nonsegmented HCV genome is 9.6-kb and encodes a long polyprotein that is cleaved by cellular and viral proteases into at least 10 distinct products. The N-terminal region of this polyprotein encodes the viral structural proteins: core and two envelope glycoproteins, E1 and E2. The remainder of the polyprotein encodes nonstructural (NS) proteins: p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B. NS4A is the smallest NS protein. It encodes an N-terminal hydrophobic alpha-helix that anchors NS3-4A to cellular membranes, a middle “cofactor” peptide that forms a beta-strand and contributes to proper folding of the NS3 serine protease domain, and a C-terminal acidic region that forms an alpha-helix at low pH.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22745131?dopt=Abstract
