Product Name: HDAC1/2 (Ser423/424) Polyclonal Antibody, Cy3 Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: Cy3
Host: Rabbit
Sourcr: KLH conjugated synthetic phosphopeptide derived from human HDAC1 around phosphorylation site of Ser423
Clonality: Polyclonal
CAS NO: 873697-71-3
Product: DOXO-EMCH
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: HD 1 Phospho Ser423; HD1; HDAC 1 Phospho Ser423; histone deacetylase 1 Phospho Ser423; Histone deacetylase 1 HD1 Phospho Ser423; Histone deacetylase 1; RPD3 reduced potassium dependency yeast homolog like 1; RPD3 reduced potassium dependency; RPD3; RPD3L1; HDAC2_HUMAN. HDAC2 Phospho Ser424; Histone deacetylase 2 Phospho Ser424.
Background: Reversible acetylation of highly conserved lysine residues within the N-terminal tail domains of core histones, plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation is a dynamic process determined by the net activities of histone acetyltransferases (HATs) and the competing enzymes histone deacetylases (HDACs). Histone deacetylases activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. Recruitment of the multiprotein complexes to promoter sites occurs by many sequence specific DNA-binding proteins such as unliganded nuclear hormone receptors, DP1-E2F, YY1 and Rb family of transcription factors, transcriptional repressors and tumor suppressors (e.g. BRCA1). Aberrant recruitment of HDACs by certain oncoproteins may occur in certain neoplastic diseases. Belongs to the histone deacetylase family.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/17967879?dopt=Abstract
