Product Name: HDAC3 (Ser424) Polyclonal Antibody, Cy5 Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Rat
Conjugation: Cy5
Host: Rabbit
Sourcr: KLH conjugated synthetic phosphopeptide derived from human HDAC3 around the phosphorylation site of Ser424
Clonality: Polyclonal
CAS NO: 53910-25-1
Product: HhAntag
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: HDAC3 phospho S424; HDAC3 phospho Ser424; p-HDAC3 Ser424; RPD3 2; RPD3-2; HD 3; HD3; HDAC 3; Histone deacetylase 3 HD3 RPD3-2; histone deacetylase 3; RPD 3; RPD3; SMAP 45; SMAP-45; SMAP45; HDAC3_HUMAN.
Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24096523?dopt=Abstract
