Product Name: HDAC4 + 5 + 9 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: ALEXA FLUOR® 594
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human HDAC4 + 5 + 9
Clonality: Polyclonal
CAS NO: 124083-20-1
Product: Mibefradil
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: AHO3 ;Antigen NY-CO-9 ;BDMR ;HA6116 ;HD4 ;HD5 ;HD7 ;HD7b ;HD9 ;HDAC ;HDAC-4 ;HDACA ;HDAC4 ;HDAC5 ;HDAC7 ;HDAC7B ;HDAC9 ;HDAC9B ;HDAC9FL ;HDACA ;HDRP ;Histone deacetylase 4 ;Histone deacetylase 5 ;Histone deacetylase 7B ;Histone deacetylase 9 ;Histone deacetylase-related protein ;MEF2-interacting transcription repressor MITR ;MITR ;NY-CO-9; HDAC4_HUMAN; HDAC5_HUMAN; HDAC9_HUMAN.
Background: In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-7, have been identified as histone deacetylases. Mammalian HDAC7 interacts with the adaptor mSin3A. The interaction of HDAC7 with mSin3A suggests the association of multiple repression complexes of transcription factors.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22428048?dopt=Abstract
