Product Name: HEATR7B2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: ALEXA FLUOR® 555
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human HEATR7B2
Clonality: Polyclonal
CAS NO: 129830-38-2
Product: M2 ion channel blocker
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: DKFZp781F0822; FLJ40243; HEAT repeat family member 7B2; HEAT repeat-containing protein 7B2; Heatr7b2; HTRB2_HUMAN; RGD1305413; XVHEAT repeat family member 7B2.
Background: HEAT repeats form rod-like helical structures that are involved in intracellular transport. HEATR7B2 (HEAT repeat-containing protein 7B2) is a 1,585 amino acid protein that contains fifteen HEAT repeats. Existing as two alternatively spliced isoforms, the gene encoding HEATR7B2 maps to human chromosome 5p13.1 and mouse chromosome 15 A1. Chromosome 5 contains 181 million base pairs and comprises nearly 6% of the human genome. Cockayne syndrome is associated with chromosome 5 through the ERCC8 gene and familial adenomatous polyposis via the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24759320?dopt=Abstract
