Product Name: Hepatitis C Virus NS5a Antibody
Applications: WB, IHC-P, IF(IHC-P)
Reactivity: Virus
Conjugation: Unconjugated
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from Hepatitis C Virus NS5a
Clonality: Polyclonal
CAS NO: 870281-82-6
Product: WIN 55,212-2 (Mesylate)
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Synonyms: HCV; HCV Non-structural protein 5A; Non-structural protein 5A; NS5a; p56; HCV NS5a; POLG_HCVBK.
Background: HCV is classified into the genus Hepacivirus of the family Flaviviridae. Like all the members of the family, HCV is an enveloped, single-stranded, positive-sense RNA virus. Its genome (about 9600 nt) is flanked at both termini by conserved, highly structured non-translated regions (NTRs) and encodes a polyprotein precursor (about 3000 aa), which is proteolytically processed by host and viral proteases to produce the structural (core, E1, E2 and p7) and non-structural (NS2, NS3, NS4A, NS4B, NS5A and NS5B) proteins of the virus. Recently, an additional protein has been identified, whose function remains unknown. NS5A is a ~56 kDa pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24361424?dopt=Abstract
