Product Name: HDAC2 (1194CT18.5.1) Monoclonal Antibody
Applications: WB
Reactivity: Human, Mouse
Conjugation: Unconjugated
Host: Mouse
Sourcr: This HDAC2 antibody is generated from a mouse immunized with a recombinant protein between 202-488 amino acids from the Central region of human HDAC2.
Clonality: Monoclonal
CAS NO: 193611-72-2
Product: HDAC-IN-1
Isotype: IgG1
Concentration:
Purification: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Storage: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Synonyms: HD2; RPD3; YAF1; Histone deacetylase 2; HDAC2
Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26224309?dopt=Abstract
